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Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty

null

《医学前沿（英文）》 2018年 第12卷 第2期   页码 174-181 doi: 10.1007/s11684-017-0544-5

摘要：

The relationship between vitamin D deficiency and idiopathic central precocious puberty (ICPP) has been recently documented. In this study, 280 girls diagnosed with ICPP and 188 normal puberty control girls of similar ages were enrolled and retrospectively studied. The ICPP group had significantly lower serum 25-hydroxyvitamin D (25[OH]D) levels than the control group. Furthermore, a nonlinear relationship was found between serum 25[OH]D and ICPP, and a cut-off point for serum 25[OH]D was found at 31.8 ng/ml for ICPP with and without adjusting the different confounding factors. Girls with serum 25[OH]D≥31.8 ng/ml had a lower odds ratio (unadjusted: OR 0.36, 95% CI 0.15 to 0.83, <0.05; height and weight adjusted: OR 0.44, 95% CI 0.18 to 1.08, = 0.072; BMI adjusted: OR 0.36, 95% CI 0.16 to 0.84, <0.05). The ICPP subjects with 25[OH]D deficiency had a higher body mass index (BMI) than the subjects from the two other subgroups. Correlation analysis showed that vitamin D level is correlated with BMI and some metabolic parameters in the ICPP group. Our study suggested that vitamin D status may be associated with ICPP risk and may have a threshold effect on ICPP.

关键词： idiopathic central precocious puberty     threshold effects     vitamin D status    

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Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: anovel model of obesity and puberty

null

《医学前沿（英文）》 2017年 第11卷 第2期   页码 266-276 doi: 10.1007/s11684-017-0530-y

摘要：

Childhood obesity and obesity-related metabolic complications are induced by a high-fat postnatal diet. The lack of a suitable animal model, however, remains a considerable challenge in obesity studies. In the current study, we provided high-fat diet (HFD) to dams during lactation and to pups after weaning. We also developed a novel model of C57BL/6J mouse pups with HFD-induced postnatal obesity. Results showed that feeding with HFD induces fat deposition and obesity in pups. Furthermore, HFD more potently increased the body weight (BW) of male than female pups. HFD-fed female pups were obese, underwent precocious puberty, and showed increased kisspeptin expression in the hypothalamus. However, parental obesity and precocious puberty exerted no synergistic effects on the HFD-induced postnatal weight gain and puberty onset of the pups. Interestingly, some HFD-fed litters with normal BW also exhibited precocious puberty. This finding suggested that diet composition but not BW triggers puberty onset. Our model suggests good construction validity of obesity and precocious puberty. Furthermore, our model can also be used to explore the mutual interactions between diet–induced postnatal childhood obesity and puberty.

关键词： postnatal HFD feeding     obesity     kisspeptin     HPG axis     precocious puberty    

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Serum erythropoietin and transferrin in children with idiopathic nephrotic syndrome

LU Hongzhu, LIU Dan, ZHANG Wanming, YUAN Yuesha, KUANG Hongyan, WANG Lin, FAN Qihong

《医学前沿（英文）》 2008年 第2卷 第3期   页码 286-289 doi: 10.1007/s11684-008-0054-6

摘要： Idiopathic nephrotic syndrome (INS) is characterized by marked urinary excretion of albumin and other intermediate-sized plasma proteins, such as transferrin and vitamin D-binding protein. Some cases even develop anemia. The aim of this study was to investigate the changes in serum iron, transferrin, and erythropoietin, and the relationships between serum and urine transferrin and erythropoietin. Thirty-seven children with INS and 35 age- and sex-matched healthy children were investigated. The indexes related to iron metabolism, including serum iron, ferritin, transferrin, total iron-binding capacity (TIBC), transferrin saturation, and hematological parameters [hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH)], and urinary transferrin and erythropoietin were measured in 37 children with INS before treatment and at the remission stage. Thirty-five age- and sex-matched healthy children served as controls. Serum iron levels (18.8 ± 3.8) ?mol/L in INS patients before treatment were significantly lower than those of the healthy controls (22.2 ± 3.8) ?mol/L and those measured at the remission stage (21.0 ± 3.5) ?mol/L (all < 001). Serum transferrin levels in INS patients before therapy (1.9 ± 0.3) g/L also decreased compared with the healthy controls (3.1 ± 0.5) g/L and the measures at the remission stage (2.9 ± 0.6) g/L (all < 0.01). In contrast, serum TIBC and transferrin saturation were significantly higher in INS patients before treatment than in the healthy controls [TIBC (56.4 ± 9.2) ?mol/L (50.7 ± 6.8) ?mol/L, < 0.01; transferrin saturation (55.7±9.2)% (46.4 ± 8.2)%, < 0.01] and they were also higher than the measures at remission stage [(51.9 ± 7.7) ?mol/L and (47.4 ± 13.3) ?mol/L] (all < 0.01). Serum transferrin was positively correlated with serum albumin ( = 0.609, < 0.01) and negatively correlated with urinary transferrin ( = -0.550, < 0.01) in INS patients before treatment. We conclude that serum iron, transferrin and erythropoietin levels are markedly decreased in INS patients, which may be partially related to the urinary loss of these indexes.
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Sensitivity of supplementation of thyroid hormone on treatment of idiopathic short-stature children during

Wei Wang, Shuqin Jiang, Zhirui Cui, Xiangyang Luo, Lingli Shi, Heli Zheng

《医学前沿（英文）》 2018年 第12卷 第5期   页码 580-585 doi: 10.1007/s11684-017-0585-9

摘要：

This study aimed to evaluate the effects of thyroid hormone supplementation on growth rate of children with idiopathic short stature (ISS) and low-normal serum free thyroxine FT4 who were receiving growth hormone therapy. We selected 64 prepubertal children with FT4 levels in the lowest third of the normal range as the lower FT4 group, and these children were divided randomly into two subgroups: L-thyroxine (L-T4)-treated subgroup was treated with L-T4 (0.5–3.0 g/(kg·d)) from the beginning of the study, and the non-L-T4-treated subgroup received placebo. We also selected 39 ISS children with FT4 in the upper two-thirds of the normal range as the higher FT4 group. During the first year, the lower FT4 group featured lower FT3, FT4, thyroid stimulating hormone (TSH), and insulin-like growth factor-I standard deviation score (IGF-I SDS) and significantly lower height velocity (HV) compared with the higher FT4 group. However, in the lower FT4 group, the L-T4-treated subgroup presented higher FT4, FT3, TSH, and IGF-I SDS concentrations and significantly higher HV compared with children in the non-L-T4-treated subgroup. In children with ISS, the negative effect of thyroid hormone deficiency on growth rate should be considered when FT4 level lies in the low-normal range prior to recombinant human growth hormone treatment.

关键词： therapeutic     idiopathic short-stature children     free T4     the first year     recombinant human growth hormone    

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Multiscale RBF-based central high resolution schemes for simulation of generalized thermoelasticity problems

Hassan YOUSEFI, Alireza TAGHAVI KANI, Iradj MAHMOUDZADEH KANI

《结构与土木工程前沿（英文）》 2019年 第13卷 第2期   页码 429-455 doi: 10.1007/s11709-018-0483-5

摘要： In this study, average-interpolating radial basis functions (RBFs) are successfully integrated with central high-resolution schemes to achieve a higher-order central method. This proposed method is used for simulation of generalized coupled thermoelasticity problems including shock (singular) waves in their solutions. The thermoelasticity problems include the LS (systems with one relaxation parameter) and GN (systems without energy dissipation) theories with constant and variable coefficients. In the central high resolution formulation, RBFs lead to a reconstruction with the optimum recovery with minimized roughness on each cell: this is essential for oscillation-free reconstructions. To guarantee monotonic reconstructions at cell-edges, the nonlinear scaling limiters are used. Such reconstructions, finally, lead to the total variation bounded (TVB) feature. As RBFs work satisfactory on non-uniform cells/grids, the proposed central scheme can handle adapted cells/grids. To have cost effective and accurate simulations, the multiresolution–based grid adaptation approach is then integrated with the RBF-based central scheme. Effects of condition numbers of RBFs, computational complexity and cost of the proposed scheme are studied. Finally, different 1-D coupled thermoelasticity benchmarks are presented. There, performance of the adaptive RBF-based formulation is compared with that of the adaptive Kurganov-Tadmor (KT) second-order central high-resolution scheme with the total variation diminishing (TVD) property.

关键词： central high resolution schemes     RBFs     higher order accuracy     generalized thermoelasticity     multiresolution-based adaptation    

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Degradation of refractory organics in concentrated leachate by the Fenton process: Central composite

Senem Yazici Guvenc, Gamze Varank

《环境科学与工程前沿（英文）》 2021年 第15卷 第1期 doi: 10.1007/s11783-020-1294-1

摘要： Abstract • 90% total COD, 95.3% inert COD and 97.2% UV254 were removed. • High R2 values (over 95%) for all responses were obtained with CCD. • Operational cost was calculated to be 0.238 €/g CODremoved for total COD removal. • Fenton oxidation was highly-efficient method for inert COD removal. • BOD5/COD ratio of leachate concentrate raised from 0.04 to 0.4. The primary aim of this study is inert COD removal from leachate nanofiltration concentrate because of its high concentration of resistant organic pollutants. Within this framework, this study focuses on the treatability of leachate nanofiltration concentrate through Fenton oxidation and optimization of process parameters to reach the maximum pollutant removal by using response surface methodology (RSM). Initial pH, Fe2+ concentration, H2O2/Fe2+ molar ratio and oxidation time are selected as the independent variables, whereas total COD, color, inert COD and UV254 removal are selected as the responses. According to the ANOVA results, the R2 values of all responses are found to be over 95%. Under the optimum conditions determined by the model (pH: 3.99, Fe2+: 150 mmol/L, H2O2/Fe2+: 3.27 and oxidation time: 84.8 min), the maximum COD removal efficiency is determined as 91.4% by the model. The color, inert COD and UV254 removal efficiencies are determined to be 99.9%, 97.2% and 99.5%, respectively, by the model, whereas the total COD, color, inert COD and UV254 removal efficiencies are found respectively to be 90%, 96.5%, 95.3% and 97.2%, experimentally under the optimum operating conditions. The Fenton process improves the biodegradability of the leachate NF concentrate, increasing the BOD5/COD ratio from the value of 0.04 to the value of 0.4. The operational cost of the process is calculated to be 0.238 €/g CODremoved. The results indicate that the Fenton oxidation process is an efficient and economical technology in improvement of the biological degradability of leachate nanofiltration concentrate and in removal of resistant organic pollutants.

关键词： Concentrated leachate     Fenton oxidation     Central composite design     Biodegradability     Inert COD    

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Development of a multi-component drug from turmeric using central composite design

Xiaohang ZHANG,Shengnan HAN,Yan LI,Jianlan JIANG

《化学科学与工程前沿（英文）》 2014年 第8卷 第3期   页码 362-368 doi: 10.1007/s11705-014-1439-5

摘要： A methodology to develop multi-component drugs based on traditional Chinese medicines has been developed using central composite design. Several active components from the traditional Chinese medicine turmeric were chosen for use in a multi-component antitumor drug. Response surface methodology based on a central composite design was applied to determine the quantitative composition-activity relationships in order to optimize the amount of each component in the drug. An MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was used to measure the pharmacological activity as the response value. The experimental antitumor activity of the optimum combination was 92.85% in the MTT assay and superior to the activities of each single component. These results demonstrate that response surface methodology based on a central composite design is suitable for the design of multi-component drugs.

关键词： multi-component drug development     central composite design     turmeric     curcuminoids    

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Anterior cervical surgery methods for central cord syndrome without radiographic spinal fracture-dislocation

Chengwei JING, Qin FU, Xiaojun XU

《医学前沿（英文）》 2009年 第3卷 第1期   页码 45-48 doi: 10.1007/s11684-009-0019-4

摘要： This study was aimed to explore the anterior cervical surgery methods to treat central cord syndrome without radiographic spinal fracture-dislocation (CCSWORFD), retrospectively analyze the cases of CCSWORFD, and evaluate the curative effect of anterior cervical surgery methods for CCSWORFD. Twenty four cases of CCSWORFD (19 males and 5 females), all suffering from cervical hyperextension injury, between 45-68 (average 59) years old, were operated on by anterior cervical surgery methods. Among these, 18 cases had been followed up for 6-24 (average 15) months; 18 cases, who had anterior decompression and plate fixation with titanium mesh bone grafting or iliac bone grafting achieved reliable effects based on the Japanese Orthopedics Association (JOA) evaluation (improved scores of cases with titanium mesh bone grafting, = 2.800, <0.05; improved scores of cases with iliac bone grafting, = 3.270, <0.05), and reliable reconstruction of cervical spine. The two groups obtained the same curative effect ( = 0.470, >0.05) Most of these cases had degeneration of cervical vertebra. The decompression which relieves the oppression to the spinal cord can help lessen edema of the spinal cord, and early fixation for stability of cervical vertebra is better for the recovery of spinal cord injury. Anterior operation with titanium mesh bone grafting or iliac bone grafting are both reliable curative methods for CCSWORFD, and titanium mesh bone grafting can avoid the trauma of the supplying graft. Mesh bone grafting can also shorten hospital stay.

关键词： central cord syndrome     decompression     surgical     titanium mesh    

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Environment and economic feasibility of municipal solid waste central sorting strategy: a case study

Hua ZHANG, Zongguo WEN, Yixi CHEN

《环境科学与工程前沿（英文）》 2016年 第10卷 第4期 doi: 10.1007/s11783-016-0852-z

摘要： The Green House program reduced the amount of waste by 34%. The Green House is now running with a monthly loss of 1982 CNY. Involve government, expand scale, use professional technology are main suggestions. Improved program can reduce the amount of waste by 37% (33.8 tons monthly). Improved program can flip the loss into a profit worth 35034 CNY monthly. Although Beijing has carried out municipal solid waste (MSW) source separation since 1996, it has largely been ineffective. In 2012, a “Green House” program was established as a new attempt for central sorting. In this study, the authors used material flow analysis (MFA) and cost benefit analysis (CBA) methods to investigate Green House’s environment and economic feasibility. Results showed that the program did have significant environmental benefits on waste reduction, which reduced the amount of waste by 34%. If the Green House program is implemented in a residential community with wet waste ratio of 66%, the proportion of waste reduction can reach 37%. However, the Green House is now running with a monthly loss of 1982 CNY. This is mainly because most of its benefits come from waste reduction (i.e., 5878 CNY per month), which does not turn a monetary benefit, but is instead distributed to the whole of society as positive environmental externalities. Lack of government involvement, small program scale, and technical/managerial deficiency are three main barriers of the Green House. We, thus, make three recommendations: involve government authority and financial support, expand the program scale to separate 91.4 tons of waste every month, and use more professional equipment/technologies. If the Green House program can successfully adopt these suggestions, 33.8 tons of waste can be reduced monthly, and it would be able to flip the loss into a profit worth 35034 CNY.

关键词： Environment and economic feasibility     Municipal solid waste (MSW)     Waste central sorting     Green House    

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Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

《医学前沿（英文）》   页码 889-906 doi: 10.1007/s11684-023-0994-x

摘要： Primary central nervous system lymphoma (PCNSL) is an uncommon non-Hodgkin’s lymphoma with poor prognosis. This study aimed to depict the genetic landscape of Chinese PCNSLs. Whole-genome sequencing was performed on 68 newly diagnosed Chinese PCNSL samples, whose genomic characteristics and clinicopathologic features were also analyzed. Structural variations were identified in all patients with a mean of 349, which did not significantly influence prognosis. Copy loss occurred in all samples, while gains were detected in 77.9% of the samples. The high level of copy number variations was significantly associated with poor progression-free survival (PFS) and overall survival (OS). A total of 263 genes mutated in coding regions were identified, including 6 newly discovered genes (ROBO2, KMT2C, CXCR4, MYOM2, BCLAF1, and NRXN3) detected in ≥ 10% of the cases. CD79B mutation was significantly associated with lower PFS, TMSB4X mutation and high expression of TMSB4X protein was associated with lower OS. A prognostic risk scoring system was also established for PCNSL, which included Karnofsky performance status and six mutated genes (BRD4, EBF1, BTG1, CCND3, STAG2, and TMSB4X). Collectively, this study comprehensively reveals the genomic landscape of newly diagnosed Chinese PCNSLs, thereby enriching the present understanding of the genetic mechanisms of PCNSL.

关键词： primary central nervous system lymphoma     whole-genome sequencing     TMSB4X     copy number variation     gene mutation    

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Making central-local relations work: Comparing America and China environmental governance systems

Dan GUTTMAN, SONG Yaqin

《环境科学与工程前沿（英文）》 2007年 第1卷 第4期   页码 418-433 doi: 10.1007/s11783-007-0068-3

摘要： The challenge of making central requirements work at local levels is a common problem for environmental governance throughout the world. Countries can learn from one another s approaches, but must understand the local context in w
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模糊中心聚类的模式识别学习方法

曾黄麟,袁慧,刘小芳

《中国工程科学》 2004年 第6卷 第11期   页码 33-37

摘要：

基于一个约束条件下的非线性规划问题的优化计算思想，把模糊中心聚类中计算输入矢量与中心的距离来实现聚类作为一种优化计算问题，证明了模糊中心聚类方法，取一个适当的属函数，其聚类中心vi为模糊聚类中心价值函数的极小值，推导出了基于模糊中心聚类的模式识别的无导师递推学习方法，提出了模糊中心聚类模式分类神经网络结构，该网络可以实现并行数据处理和模式分类的软划分和硬划分。

关键词： 模糊     中心聚类     模式识别     神经网络    

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Distributed fiber optic monitoring of a CFA pile with a central reinforcement bar bundle

Yi RUI, Nicholas de BATTISTA, Cedric KECHAVARZI, Xiaomin XU, Mei YIN

《结构与土木工程前沿（英文）》 2021年 第15卷 第1期   页码 167-176 doi: 10.1007/s11709-020-0581-z

摘要： In this paper, we present an application of distributed fiber optic sensor (DFOS) technology to measure the strain of a continuous flight auger (CFA) test pile with a central reinforcement bar bundle, during a static load test carried out in London. Being distributed in nature, DFOS gives much more information about the pile performance as compared to traditional point sensors, such as identifying cross-sectional irregularities or other anomalies. The strain profiles recorded along the depth of the piles from the DFOS were used to calculate pile deformation (contraction), shaft friction, and tip resistance under various loads. Based on this pile load test, a finite element (FE) analysis was performed using a one-dimensional nonlinear load-transfer model. Calibrated by the shaft friction and tip resistance derived from the monitored data, the FE model was able to simulate the pile and soil performance during the load testing with good accuracy. The effect of the reinforcement cage and central reinforcement bar bundle were investigated, and it was found that the addition of a reinforcement cage would reduce the pile settlement by up to 20%.

关键词： continuous flight auger pile     static load test     central reinforcement bar bundle     distributed fiber optic sensor     finite element     load transfer    

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Flutter control effect and mechanism of central-slotting for long-span bridges

YANG Yongxin, GE Yaojun, XIANG Haifan

《结构与土木工程前沿（英文）》 2007年 第1卷 第3期   页码 298-304 doi: 10.1007/s11709-007-0039-6

摘要： The flutter control effect and mechanism of central-slotting, which have gradually been adopted in the design and construction of long-span bridges as an effective flutter controlling measure, were investigated with theoretical analysis and wind tunnel test. Five basic girder cross-sections representing five typical aerodynamic configurations were selected and central-slotted with two different slot widths. Then, a series of sectional model tests and theoretical analyses based on the two-dimensional three-degrees-of-freedom coupling flutter analysis method (2 dimension-3 degrees of freedom method, 2d-3DOF method) were carried out to investigate the aerodynamic performance, flutter mechanism and flutter modality of the five basic sections and their corresponding central-slotted sections. The results show that central-slotting can not always improve the aerodynamic stability of bridge structure. The control effect of central-slotting depends on the aerodynamic configuration of the original girder section and the corresponding central-slotting width. If the original section is inappropriate or the slot width is unsuitable, central-slotting will even deteriorate the structural flutter performance. Theoretical investigations indicated that the differences in flutter control effects come from the different formation and evolution of aerodynamic damping, and flutter modality especially the participation level of heaving motion also has a significant influence on the control effect of central-slotting.

关键词： aerodynamic configuration     aerodynamic performance     flutter mechanism     aerodynamic stability     theoretical analysis    

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Problems of Syrdarya river basin management

Serdar EYEBERENOV, Baijing CAO, Fengting LI

《环境科学与工程前沿（英文）》 2009年 第3卷 第2期   页码 221-225 doi: 10.1007/s11783-009-0015-6

摘要： Prior to independence, Central Asian countries were closely interconnected through the regional management incorporating water, energy, and food sectors. This approach, supported by the central government of Union of Soviet Socialist Republics (USSR), functioned effectively – meeting the needs of both upstream and downstream countries. However, after independence, Central Asian countries started prioritizing their own economic development policies without due account to regional concerns such as joint use of water resources, leading to instability. In this study, the case of Syrdarya basin was investigated to show how such strategies create tension in the region, since primary focus is given to national interests, without consideration for regional problems. To address this issue, an integrated approach to incorporating water, energy, and agriculture is needed. It is suggested that a single sector approach on water alone does not lead to stability, and a multi-sectoral approach is necessary to ensure sustainable development. Countries sharing benefits from the river have to be responsible for costs of operation and maintenance of the water facilities.

关键词： Central Asia     energy     agriculture     water     Syrdarya basin    

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标题 作者 时间 类型 操作

Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty

null

期刊论文

Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: anovel model of obesity and puberty

null

期刊论文

Serum erythropoietin and transferrin in children with idiopathic nephrotic syndrome

LU Hongzhu, LIU Dan, ZHANG Wanming, YUAN Yuesha, KUANG Hongyan, WANG Lin, FAN Qihong

期刊论文

Sensitivity of supplementation of thyroid hormone on treatment of idiopathic short-stature children during

Wei Wang, Shuqin Jiang, Zhirui Cui, Xiangyang Luo, Lingli Shi, Heli Zheng

期刊论文

Multiscale RBF-based central high resolution schemes for simulation of generalized thermoelasticity problems

Hassan YOUSEFI, Alireza TAGHAVI KANI, Iradj MAHMOUDZADEH KANI

期刊论文

Degradation of refractory organics in concentrated leachate by the Fenton process: Central composite

Senem Yazici Guvenc, Gamze Varank

期刊论文

Development of a multi-component drug from turmeric using central composite design

Xiaohang ZHANG,Shengnan HAN,Yan LI,Jianlan JIANG

期刊论文

Anterior cervical surgery methods for central cord syndrome without radiographic spinal fracture-dislocation

Chengwei JING, Qin FU, Xiaojun XU

期刊论文

Environment and economic feasibility of municipal solid waste central sorting strategy: a case study

Hua ZHANG, Zongguo WEN, Yixi CHEN

期刊论文

Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

期刊论文

Making central-local relations work: Comparing America and China environmental governance systems

Dan GUTTMAN, SONG Yaqin

期刊论文

模糊中心聚类的模式识别学习方法

曾黄麟,袁慧,刘小芳

期刊论文

Distributed fiber optic monitoring of a CFA pile with a central reinforcement bar bundle

Yi RUI, Nicholas de BATTISTA, Cedric KECHAVARZI, Xiaomin XU, Mei YIN

期刊论文

Flutter control effect and mechanism of central-slotting for long-span bridges

YANG Yongxin, GE Yaojun, XIANG Haifan

期刊论文

Problems of Syrdarya river basin management

Serdar EYEBERENOV, Baijing CAO, Fengting LI

期刊论文